Early regulation of membrane excitability by ras oncogene proteins

Regulation of membrane turnover by ras proteins.

Because ras oncogenes mediate abnormal cellular growth, ras proteins have been presumed to play a role primarily in growth control. The biological function of ras proteins may, however, prove to be much more diverse: ras proteins may be involved in cellular functions that control endocytosis and/or exocytosis.

Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.

Expression and activity of lysosomal cysteine cathepsins correlate with the metastatic capacity and aggressiveness of tumors. Here, we show that transformation of murine embryonic fibroblasts with v-H-ras or c-src(Y527F) changes the distribution, density, and ultrastructure of the lysosomes, decreases the levels of lysosome-associated membrane proteins (LAMP-1 and LAMP-2) in an extracellular si...

Correlation of Thyroid Hormone Dose-dependent Regulation of K-ras Proto oncogene Expression with Oncogene Activation by 3-Methylcholanthrene: Loss of Thyroidal Regulation in the Transformed Mouse Cell1

Previously, it has been demonstrated that thyroid hormone is an important cofactor of the initiation of oncogenesis in viro and in vitro. In order to determine the mechanism of thyroid hormone modulation of the initiation of carcinogenesis we have addressed the hypothesis that thyroid hormone regulates the expression of the critical protooncogene at the time of exposure to the carcinogen, and t...

Regulation of complement by membrane proteins: an overview.

Regulation of peptidoglycan synthesis by outer membrane proteins

Growth of the mesh-like peptidoglycan (PG) sacculus located between the bacterial inner and outer membranes (OM) is tightly regulated to ensure cellular integrity, maintain cell shape, and orchestrate division. Cytoskeletal elements direct placement and activity of PG synthases from inside the cell, but precise spatiotemporal control over this process is poorly understood. We demonstrate that P...